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NVP-BKM120 is a pan-class I PI3K inhibitor, with IC 50 s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.



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NVP-BKM120 is a pan-class I PI3K inhibitor, with IC 50 s of 52, 166, 116 and 262 nM for p110α, p110β, p110δ and p110γ, respectively.

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BKM120, a biologic characterization of the 2-morpholino pyrimidine derivative, is a pan-PI3K inhibitor. In vitro: NVP-BKM120 inhibits all four class I PI3K isoforms in biochemical assays with at least 50-fold selectivity against other protein kinases.

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